【摘要】 目的分析患儿常见呼吸道感染的病原体免疫球蛋白M(IgM)抗体及其感染特点。方法采用间接免疫荧光法检测该院2015年3月至2016年2月14 379例患儿血清,分析不同性别、季节、年龄段、病种的呼吸道9项病原体感染情况。结果3 392例标本(23.59%)病原体IgM抗体检测阳性,其中肺炎支原体(MP)的阳性率最高,为18.77%;混合感染361例,主要是2种病原体的混合感染。男性患儿呼吸道病原体IgM抗体阳性率(21.46%)显著低于女性患儿(33.92%),差异有统计学意义(χ2=274.73,P<0.05)。各年龄组(0~30d、~6个月、~1岁、~3岁、~9岁、~18岁)的检出率分别为0.2%、1.8%、15.36%、34.46%、39.73%、30.73%,各组间差异有统计学意义(χ2=1 407.87,P<0.05)。秋、冬季MP检出率高(24.42%、23.01%),春季乙型流感病毒(IFu B)检出率最高(15.13%),夏、秋季嗜肺军团菌(LP)检出率较高(0.78%、0.80%);该院15个科室比较,耳鼻喉科患儿呼吸道病原体检出率最高(43.9%)。结论呼吸道病原体的感染率与性别、季节、年龄段、病种相关,针对性地进行防范,具有临床意义。更多还原

【Abstract】 Objective To detect the IgM antibodies and epidemiology of pathogens of respiratory tract infection in children,and to provide the basis for clinical diagnosis and treatment.Methods The serum of 14 379 outpatient and inpatient cases in Tianjin Children′s Hospital from March 2015 to February 2016 were detected by indirect immunofluorescence,and the respiratory tract infections of different gender,season,age and pathogens were analyzed.Results Totally 3 392specimens(23.59%)were positive for IgM antibody detection and the positive rate of MP with 18.77% was highest;361cases were mixed infection,mainly including two kinds of infection pathogens.The positive rate of respiratory pathogens in male with 21.46% was significantly lower than in female patients with 33.92%(χ2= 274.73,P<0.05).The positive rate in different ages groups(0-30 d,-6months,-1years,-3years,-9years,-18years)were 0.2%,1.8%,15.36%,34.46%,39.73% and 30.73% respectively,the highest infection rate was found between 3to 9years old children,and the differences among groups were statistically significant(χ2=1 407.87,P<0.05).The highest rate of MP were found in autumn(24.42%)and winter(23.01%),the highest rate of Influenza B virus(IFu B)was found in spring(15.13%),the positive rate of Legionella pneumophila(LP)was high in summer(0.78%)and autumn(0.80%).Comparison with the 15 departments,the children of otolaryngology with the positive rate of 43.9% was the highest.Conclusion The infection ratios of respiratory pathogens were related to gender,season,age and pathogen.These findings provided an important reference for clinical diagnosis and treatment in different seasons and population.更多还原