【摘要】 目的通过对高敏肌钙蛋白T(hs-cTnT)和普通肌钙蛋白I(cTnI)的检测,探讨hs-cTnT、cTnI在急性心肌梗死(AMI)早期诊断中的应用价值。方法选取2015年10月至2016年3月北京大学深圳医院心血管内科已确诊AMI患者100例作为观察组(AMI组),同时选取100例健康体检成年人作为对照组,采用化学发光免疫法检测hs-cTnT和cTnI水平,并比较AMI组hs-cTnT和cTnI对AMI早期诊断的阳性率、敏感度和特异度。结果 AMI组hs-cTnT水平为(4.89±1.83)ng/mL高于健康人群第99百分位值的0.014ng/mL,cTnI水平为(28.82±12.32)ng/mL高于健康人群正常参考值上限0.4ng/mL,两者水平均明显高于对照组(P<0.05),hs-cTnT的阳性率和敏感度均为92.0%,明显高于cTnI的79.0%(均P<0.05),cTnI的特异度为96.0%显著高于hs-cTnT的76.0%(P<0.05)。结论 hs-cTnT的阳性率和敏感性高,cTnI的特异性高,两者联合检测对于AMI的早期诊断具有重要意义。更多还原

【Abstract】 Objective To detect hs-cTnT and cTnI for exploring their application value in the early diagnosis of acute myocardial infarction(AMI).Methods From October 2015 to March 2016,100 patients with AMI in the cardiology department of our hospital were selected as the observation group(AMI group)and contemporaneous 100 adults undergoing physical examination as the control group.The chemiluminescence immunoassay was used to detect the levels of hs-cTnT and cTnI.The positive rate,sensitivity and specificity of the hs-cTnT and cTnI in the AMI group for early diagnosis of AMI were compared.Results The level of hs-cTnT in the AMI group was(4.89±1.83)ng/mL,which was higher than that in the healthy population by 99 percentile value 0.014ng/mL;the cTnI level in the AMI group was(28.82±12.32)ng/mL,which was higher than that in the healthy population by the upper limit of normal reference value 0.4ng/mL,both of them were significantly higher than those in the control group(P<0.05),the positive rate and sensitivity of hs-cTnT was both 92.0%,which was significantly higher than 79.0% of cTnI both(P<0.05),the specificity of cTnI was 96.0%,which was significantly higher than 76.0% of hs-cTnT(P<0.05).Conclusion The positive rate and the sensitivity of hs-cTnT are high,the specificity of cTnI is high,their joint detection has an important significance for the early diagnosis of AMI.更多还原