【摘要】 过敏性疾病在全球范围内严重影响公共健康,目前老年过敏性疾病发病率约5%~10%,并且呈持续上升趋势。老年人免疫功能随年龄增加出现减退,导致机体对外源性抗原难以形成保护性免疫应答,发生上皮屏障受损和Th2型免疫反应。了解老年人免疫系统的改变以及老年人过敏性疾病的免疫学特征,可为临床诊断与治疗提供理论基础和科学依据。本文对三种老年过敏性疾病(变应性鼻炎、过敏性哮喘和过敏性皮炎)及其免疫学状态进行综述。更多还原

【Abstract】 Allergic diseases are serious public health disease worldwide.Currently the prevalence of allergic diseases in the elderly ranges from 5%~ 10%and appears to be rising.Immune function of the elderly has gradually decreased with age,leading to difficultily form protective immune responses against exogenous antigens,epithelial barrier defects and Th2 immune response.To understand the changes of the immune system and the immunological characteristics of allergic diseases in the elderly could provide a theoretical and scientific basis for clinical diagnosis and treatment.This paper reviews three kinds of elderly allergic diseases(allergic rhinitis,allergic rhinitis and allergic dermatitis) and immunological status.更多还原