【摘要】 目的基于文献探讨胃溃疡的中医用药规律。方法检索中国学术期刊全文数据库、万方数据库1982年1月至2013年12月中医药治疗胃溃疡的相关文献,建立胃溃疡中药文献数据库,对其用药特点进行统计和分析。结果研究涉及治疗胃溃疡的中药共183味,总频次达3 489次,共有32味频次>30次且构成比>1%的中药,其总频次达2 626次,占中药总频次的75.27%,其中频次排在前5位的中药依次为甘草、白芍、延胡索、黄芪、白及;通过Apriori算法设定支持度>10%,置信度1≥50%,置信度2≥50%,相关度>1,且甘草除外的规则来挖掘各证型药对,其中脾胃阳虚证常见19对药对,以白芍-黄芪、桂枝-黄芪、白芍-桂枝为主;肝胃不和证常见17对药对,以白芍-柴胡、柴胡-香附、白芍-香附为主;气滞血瘀证常见17对药对,以白及-海螵蛸、海螵蛸-三七、白及-三七为主;脾胃气虚证常见16对药对,以白术-党参、白术-茯苓、党参-茯苓为主;胃阴虚证常见28对药对,以北沙参-麦冬、北沙参-石斛、白芍-北沙参为主。结论在辨证论治的基础上,利用数据挖掘技术整理胃溃疡用药规律,选用有效的药物及药对,可提高临床疗效。更多还原

【Abstract】 Objective To study the medication rule of gastric ulcer in traditional Chinese medicine based on literatures. Methods The literatures were searched in China Academic Journals Full-text Database and Wanfang Database from January,1982 to December,2013. The traditional Chinese medicine literatures database related to gastric ulcer was set up. The medication rule of gastric ulcer was analyzed statistically. Results The study involved183 kinds of Chinese herbs for gastric ulcer,the total frequency was 3 489. Among them,the frequency of 32 kinds of herbs was greater than 30 and the constituent ratio was above 1%. The total frequency of these 32 kinds was 2626,accounting for 75.27% of all. The frequencies at top five were liquorice,root of herbaceous peony,fumitory,astragalus and bletilla. By Apriori algorithm,we set support>10%,1 confidence level>50%,2 confidence l evel>50%and association degree > 1. Various couplet medicines were explored except liquorice based on syndrome patterns.There were 19 couplets for yang-deficiency of both spleen and stomach( root of herbaceous peony-astragalus,cassiaastragalus,root of herbaceous-cassia),17 couplets for incoordination between liver and stomach( root of herbaceous peony-bupleurum,bupleurum-cyperus,root of herbaceous peony-cyperus),17 couplets for qi stagnation and blood stasis( bletilla-cuttlebone,cuttlebone-radix notoginseng,bletilla-radix notoginseng),16 couplets for qi-deficiency of both spleen and stomach( rhizome atractylodis macrocephalae-radix codonopsitis,rhizome atractylodis macrocephalae-poria,radix codonopsitis-poria),28 couplets for stomach-yin deficiency( glehnia root-ophiopogon,glehnia root-dendrobe,root of herbaceous peony-glehnia root). Conclusion On the basis of syndrome differentiation and treatment,medication rule of gastric ulcer can be sorted out by using data mining,then effective drugs and medicines can be selected to improve the clinical curative effect.更多还原