【摘要】 以碳纳米管为基底,在混酸中氧化碳纳米管,进一步接枝L-色氨酸(Trp)、磷酸(P),制备水溶性良好的L-色氨酸改性碳纳米管(Trp-ox-CNTs)和磷酸、L-色氨酸共改性碳纳米管(Trp-P-ox-CNTs);再分别与厚朴酚(M)、和厚朴酚(HK)复合,制备改性碳纳米管载药材料。采用扫描电子显微镜(SEM)、傅里叶变换红外光谱(FT-IR)、X射线衍射仪(XRD)对其形貌和结构进行表征;快速循环伏安法(CV)对复合材料进行测试,用MTT法考察载药材料体外抗肿瘤活性和细胞毒性情况。结果表明,改性碳纳米管都具有良好的水溶性;CNTs共价键合磷酸、L-色氨酸后,对正常细胞的毒性明显降低,生物相容性显著提高,复合药物载体材料表现出较好的抗肿瘤活性。更多还原

【Abstract】 In this paper,carbon nanotubes(CNTs)as substrates were oxidatized by mixed acid,and were further grafted by tryptophan(Trp)and phosphate(P)for preparing modified carbon nanotubes materials with better water solubility(Trp-P-ox-CNTs and Trp-ox-CNTs).Then the modified carbon nanotubes were recombined with honokiol(HK)and magnolol(M),respectively.These drug carriers based on carbon nanotubes were obtained.The morphology and microstructure of the modified carbon nanotubes were characterized by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR)and X-ray diffraction(XRD).These drug carriers were characterized by cyclic voltammetry(CV)and their in vitro antitumor activity and cell toxicity were analysed by MTT assay.These results showed that the functionalized carbon nanotubes have good solubility in water.After covalent bonding with phosphate,tryptophan the toxicity of CNTs to normal cells is,reduced significantly,their biocompatibility is observably improved,and these combination drug carrier materials exhibit good anti-tumor activity.更多还原