【摘要】 目的观察玉屏风颗粒和匹多莫德对反复呼吸道感染患儿的临床疗效及对体液免疫水平的影响。方法 100例反复呼吸道感染患儿随机分为对照组和试验组,每组50例。对照组口服匹多莫德0.4 g,每天2次,2周后每次口服匹多莫德0.4 g,每天1次;试验组每天冲服玉屏风颗粒,1³岁患儿5 g,4⁶岁患儿7.5 g,7⁹岁患儿10 g,10¹4岁患儿15 g,分3次服用,2组均连续治疗3个月。比较2组患儿的临床疗效、免疫水平、肿瘤坏死因子-α（TNF-α）和白细胞介素-2（IL-2）水平。结果治疗后,试验组总有效率为96.00%（48/50例）,对照组总有效率为84.00%（42/50例）,差异有统计学意义（P<0.05）。治疗后,试验组免疫球蛋白A（Ig A）为（1.51±0.17）g·L^-1,免疫球蛋白G（Ig G）为（11.94±2.32）g·L^-1,免疫球蛋白M（Ig M）为（1.68±0.32）g·L^-1;对照组Ig A为（1.01±0.21）g·L^-1,Ig G为（8.08±2.07）g·L^-1,Ig M为（1.29±0.38）g·L^-1,与治疗前相比,差异有统计学意义（均P<0.01）,试验组与对照组相比差异有统计学意义（均P<0.01）。试验组治疗后TNF-α为（0.32±0.19）ng·m L^-1,IL-2为（16.46±9.34）ng·m L^-1;对照组的TNF-α为（0.83±0.29）ng·m L^-1,IL-2为（53.14±20.63）ng·m L^-1（P<0.05）。治疗中未出现恶心、呕吐、腹泻、皮疹等药物不良反应。结论反复呼吸道感染用玉屏风颗粒治疗能够改善患者体液免疫水平。更多还原

【Abstract】 Objective To observe the clinical effect and immunity effect of pidotimod and Yupingfeng in children with recurrent respiratory tract infection. Methods A total of 100 cases of recurrent respiratory tract infection children were randomly divided into control and treatment group,50 cases in each group. Control group was treated with pidotimod0. 4 g,2 times a day,after two weeks,orally given pidotimod 0. 4 g,1times a day. Treatment group was treated with Yupingfeng particles,1-3 years old children 5 g,4- 6 years old children 7. 5 g,7- 9 years old children 10 g,10^-14 years old children 15 g,three times daily. All children were treated for 3 months. The clinical efficacy of the two groups and the levels of immunity,tumor necrosis factor- α（ TNF- α） and interleukin- 2（ IL- 2） in two groups were observed. Results The total effective rate in treatment group was 96. 00%（ 48 /50）,had significantdifference with 84. 00%（ 42 /50） in control group（ P < 0. 05）. The immunoglobulin A（ Ig A）,immunoglobulin G（ Ig G）,immunoglobulin M（ Ig M） were（ 1. 51 ± 0. 17）,（ 11. 94 ± 2. 32）,（ 1. 68 ± 0. 32） g·L^-1in treatment group,had significant difference with（ 1. 01 ± 0. 21）,（ 8. 08 ± 2. 07）,（ 1. 29 ± 0. 38） g·L^-1in control group（ P < 0. 01）.After treatment,the TNF- α and IL- 2 in treatment group were（ 0. 32 ± 0. 19）,（ 16. 46 ± 9. 34） ng·m L^-1,had significant difference with（ 0. 83 ± 0. 29）,（ 53. 14 ± 20. 63） ng·m L^-1in control group（ P < 0. 05）. Nausea,vomiting,diarrhea,skin rashes and other adverse drug reactions were not happened in two groups. Conclusion Yupingfeng particles can improve the humoral immunity level in children with recurrent respiratory tract infection.更多还原