【摘要】 目的观察拉坦前列素降眼压疗效与前列腺素受体基因(PTGFR)多态性的相关性。方法纳入临床确诊的高眼压症患者和原发性开角型青光眼患者70例,用荧光染色原位杂交法确定PTGFR基因单核苷酸多态性(SNPs)位点rs3766355、rs3753380的基因型,分析其与拉坦前列素降眼压疗效的关系。结果 65例原发性开角型青光眼患者和高眼压症患者前列腺素受体的rs3766355位点CC+CA型的有效率高于AA型(P<0.05);rs3753380位点TT+TC型较CC型的有效率差异无统计学意义(P>0.05)。结论 PTGFR基因rs3766355位点基因多态性与拉坦前列素的降眼压疗效可能相关。更多还原

【Abstract】 Objective To study the association between the efficacy of latanoprost in lowing intraocular pressure and genetic polymorphisms of prostaglandin receptor( PTGFR) gene. Methods A pharmacogenetic analysis was performed by using fluorescence in situ hybridization( FISH)to analyze the genotype of single nucleotide polymorphism( SNPs)( rs3766355, rs3753380) in patients with ocular hypertension and primary open- angle glaucoma who were treated with latanoprost.Results Sixty- five partients completed follow- up. The CC + CA genotypes in rs3766355 may be of high response to latanoprost versus AA genotype in patients with ocular hypertension or primary open- angle glaucoma( P < 0. 05),but no significant difference was found among TT + TC versus CC genotype in rs3753380( P > 0. 05). Conclusion SNP of rs3766355 in PTGFR may be associated with the effect of latanoprost.更多还原