【摘要】 目的分析双侧原发性乳腺癌患者的临床和病理因素,探讨其对患者预后的影响。方法分析行乳腺癌手术4550例中经病理组织学证实的双侧原发性乳腺癌(BPBC)110例的临床和病理资料,分析双侧乳腺癌的临床和病理因素与预后的关系。结果同时性双侧乳腺癌25例(22.7%),异时性双侧乳腺腺癌85例(77.3%),接受手术、化学治疗、内分泌治疗等综合治疗。3,5,8年的总生存率分别为72.7%(80/110),51.8%(57/110),44.5%(49/110);原发肿瘤大小、有否淋巴结转移、治疗和两侧乳腺癌的间距时间等均影响预后。结论临床和病理因素对于鉴别诊断BPBC对侧是转移性病灶还是第2原发癌十分重要。手术、化学治疗、内分泌治疗等综合治疗可延长BPBC的生存率。早期发现对侧乳腺癌对改善肿瘤分期至关重要。更多还原

【Abstract】 Objective To analyze the clinical and pathologic factors of bilateral primary breast cancer( BPBC),and explore the influence on prognosis. Methods To collect clinical and pathologic data of 110 patients with BPBC. Results In 110 cases,there were 25 synchronous bilateral primary breast cancer( s BPBC) and 85 metachronous bilateral primary breast cancer( m BPBC). All cases were given operation,chemotherapy and endocrine therapy. The overall survival rate of 3,5,8 years in BPBC were 72. 7%( 80 /110), 51. 8%( 57 /110) and 44. 5%( 49 /110),respectively. By multivariate analysis,the tumor size,lymph node status and adjuvant hormone therapy were the independent risk factors for prognosis. Conclusion The clinical and pathologic factors may play an important role in the differential diagnosis of BPBC as a metastatic lesion or the second primary cancer. Endocrine therapy,chemotherapy and trastuzumab therapy can prolonged the survival rate of BPBC. The early detection of BPBC is vital for improving the staging of contralateral breast cancer.更多还原