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阿尔茨海默病与相关炎性因子
Alzheimer’s disease and related inflammatory factors
【摘要】 阿尔茨海默病是一种常见的慢性神经退行性疾病,研究显示AD患者脑组织、血液及脑脊液中白介素-18、白介素-1β、肿瘤坏死因子-α、补体等炎性因子水平异常增高,因而推测相关炎症因子在AD发病机制中起重要作用。
【Abstract】 Alzheimer’s disease(AD) is a common form of chronic and neurodegenerative disease. Studies show that the lever of inflammatory factors like interleukin- 18, interleukin- 1β, tumor necrosis factora- αand addiment which come from AD’s brain tissue, serum and cerebrospinal fluids have found out higher than those come from normal control. So it can be speculated that related inflammatory factors may play an important role in the pathogenesis of AD.
【关键词】 阿尔茨海默病;
核苷酸结合寡聚化结构域样受体蛋白1;
白介素-18;
白介素-1β;
肿瘤坏死因子-α;
补体;
【Key words】 Alzheimer’s disease; nucleotide-binding oligomerization domain-like receptor protein1; Interleukin-18; Interleukin-1β; tumor necrosis factora-α; alexin;
【Key words】 Alzheimer’s disease; nucleotide-binding oligomerization domain-like receptor protein1; Interleukin-18; Interleukin-1β; tumor necrosis factora-α; alexin;
【基金】 国家自然科学基金资助项目(81260174)
- 【文献出处】 华夏医学 ,Acta Medicinae Sinica , 编辑部邮箱 ,2016年06期
- 【分类号】R749.16
- 【被引频次】5
- 【下载频次】221