【摘要】 目的探究原发性胆汁性肝硬化发生食管胃静脉曲张的危险因素。方法选取184例原发性胆汁性肝硬化患者作为研究对象,收集患者的病程、年龄、性别以及实验室检查结果白蛋白、总胆红素(TBil)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、凝血酶原时间(PT)、血小板(PLT)、Mayo评分为相关临床指标,对这些指标进行Logistic回归分析,找出原发性胆汁性肝硬化患者发生食管胃静脉曲张的独立危险因素。结果 184例原发性胆汁性肝硬化患者中,108例食管胃静脉曲张患者PT、AST、TBil和Mayo评分均高于无曲张患者(P<0.01);白蛋白、PLT水平低于无曲张患者(P<0.01);性别、病程和年龄、ALP、ALT比较差异均无统计学意义(P>0.05)。根据多因素非条件Logistic回归分析结果显示,Mayo评分、PT、TBil升高、PLT降低为食管胃静脉曲张发生的独立危险因素预测指标,与食管胃静脉曲张的发生有相关性。结论 Mayo评分、PT、TBil升高、PLT降低对于早期预测食管胃静脉曲张具有临床意义。更多还原

【Abstract】 Objective To explore the risk factors of gastroesophageal varices in the patients with primary biliary cirrhosis. Methods 184 cases with primary biliary cirrhosis were selected as research objects, and their disease course, age, gender as well as such laboratory examination results as Alb, TBil, ALT, AST, ALP, PT, PLT, Mayo score were collected as relevant clinical indicators, which were subject to logistic regression analysis to identify independent risk factors of gastroesophageal varices in the patients with primary biliary cirrhosis. Results Of 184 cases with primary biliary cirrhosis, 108 cases with gastroesophageal varices had a higher PT, AST, TBil and Mayo score than those without esophageal variceal(P<0.01); and a lower Alb and PLT level than those without gastroesophageal varices(P<0.01); and there was no statistical difference in their gender, disease course, age, ALP and ALT(P>0.05). Multi-factor non-conditional logistic regression analysis showed that increased Mayo score, PT and TBil and decreased PLT were predictors of independent risk factors of the incidence of gastroesophageal varices, and correlated to the incidence of gastroesophageal varices. Conclusion Increased Mayo score, PT and TBil and decreased PLT are of clinical significance for early prediction of gastroesophageal varices.更多还原