A joint model with multiple change points identifying in longitudinal response process is proposed,which combines a linear mixed-effect(LME)model and an accelerated failure time(AFT)model with respect to shared covariates and random effects.All the parameters are estimated by the maximum likelihood function through the Gauss-Hermite approximation to deal with the intractable integrals in it.The effect of the method is elucidated through simulation studies and a real data application about primary biliary ci...
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