【摘要】 目的:探讨脑脊液中结核杆菌-DNA(TB-DNA)联合腺苷脱氢酶(ADA)检查对结核性脑膜炎(TBM)诊断及预后的评估价值。方法:随机选取60例非TBM患者作为对照组,60例TBM患者作为观察组。回顾性分析两组的临床资料,对比两组TB-DNA及ADA含量差异,分析TB-DNA联合ADA检查对TBM的诊断价值及TB-DNA、ADA含量与预后的相关性。结果:观察组TB-DNA及ADA含量均明显高于对照组(P<0.05);联合TB-DNA及ADA检查对TBM的诊断特异性及准确性均明显高于单纯TB-DNA检查及单纯ADA检查,虽然单纯TB-DNA检查、ADA检查及联合TB-DNA及ADA检查均对TBM存在诊断价值(P<0.05),但以联合TB-DNA及ADA检查的诊断价值最高。此外,TB-DNA及ADA含量均与GOS评分存在显著的负向直线相关性(P<0.05)。结论:联合TB-DNA及ADA检查对于TBM有着明确的诊断价值,且可用于评价患者的临床预后。更多还原

【Abstract】 Objective: To evaluate the value of tuberculosis bacili-DNA(TB-DNA) combined with adenosine dehydrogenase(ADA) in cerebrospinal fluid for the diagnosis and prognosis of tuberculous meningitis(TBM). Methods: Randomly selected 60 cases of non TBM patients as control group, 60 cases of TBM patients as observation group. Retrospective analysis of the clinical data of two groups, compared with the two groups of TB-DNA and ADA content differences, analysis of TB-DNA combined with ADA examination of the diagnostic value of TBM and TB-DNA, ADA content and prognosis of correlation. Results: The observation group TB-DNA and ADA were obviously higher than that of the control group(P<0.05); combined with TB-DNA and ADA examination in the diagnosis of TBM specificity and accuracy were significantly higher than that of pure TB-DNA examination and ADA examination alone, although only TBDNA examination, ADA examination and ADA examination were combined with TB-DNA and TBM are of diagnostic value(P<0.05). But the diagnostic value of combined TB-DNA and ADA examination of the highest. In addition, there was a significant negative linear correlation between TB-DNA and ADA content and GOS score(P<0.05). Conclusion: Combined TB-DNA and ADA examination for TBM has a clear diagnostic value, and can be used to evaluate the clinical prognosis of patients.更多还原