【摘要】 模拟天然骨组织中胶原的有序结构,构建多级有序的胶原液晶膜,以胶原非液晶膜作为参照,通过体外的仿生矿化考察了胶原液晶模板对于仿生矿化的影响。采用偏光显微镜、扫描电镜、原子力显微镜、X-射线衍射等手段分析了仿生矿化不同时间后在两种模板上沉积的钙磷盐的形貌与结构。结果表明,胶原液晶的多级有序结构对仿生矿化有比较明显的影响;与胶原非液晶模板相比,在胶原液晶模板上沉积的钙磷盐不仅在微观上有序,而且在宏观上也很有序且致密。这表明,胶原液晶的这种多级有序结构有利于构建仿生骨组织修复材料。更多还原

【Abstract】 To simulate the ordered texture of the collagen in natural bone tissue, membranes of collagen with hierarchically ordered texture were fabricated. The effect of templates made of collagen with and without ordered texture on the biomineralization process of calcium phosphate was comparatively studied in vitro. The morphology and structure of the deposited calcium phosphate on the collagen templates were characterized by using polarizing microscope(POM), scanning electron microscope(SEM),atomic force microscope(AFM) and X-ray diffraction(XRD). The results show that the collagen with hierarchically ordered texture has obvious effect on the biomimetic mineralization process; on which the deposited calcium phosphate is much more orderly and compact either in micro- or in macro scales. This result indicates that the collagen with hierarchically ordered texture is beneficial to the building of biomimetic bone tissues as materials for repair of human bone etc.更多还原