【摘要】 目的:探讨序贯性肠内营养治疗(ENT)在重症急性胰腺炎(SAP)病人治疗中的应用及临床效果。方法:将41例确诊为SAP并保守治疗的病人随机分为两组。研究组(n=21)采用短肽型EN制剂过渡至整蛋白型EN制剂的序贯性ENT方案;对照组(n=20)直接采用整蛋白型EN制剂的ENT方案,喂养过程按照相关指南实施。比较两组病人达到目标能量时间、喂养并发症的发生率、同期营养指标情况以及平均入住ICU时间的差异。结果:两组病人在一定时间内均能达到目标热量。研究组病人达到目标能量的时间早于对照组(P<0.05);研究组病人喂养并发症的发生率明显低于对照组(P<0.05);研究组病人营养指标改善情况明显好于对照组(P<0.05);研究组平均入住ICU时间短于对照组,但差异无统计学意义(P>0.05)。结论:序贯性ENT在SAP病人治疗中耐受性更好,能更快地改善病人的营养状况。更多还原

【Abstract】 Objective: To explore the feasibility and clinical effect of sequential enteral nutrition therapy in severe acute pancreatitis. Methods: 41 cases of severe acute pancreatitis with conservative treatment were randomly divided into two groups. 21 cases in the studygroup underwent sequential enteral nutrition therapy in which short-peptide products were taken as the primary choice and total-protein products were applied lately,while the other 20 cases in the control group underwent total-protein enteral nutrition immediately after initiation of enteral nutrition. The data of the two groupsincluding the time to target amount of nutritionfeeding,associatedcomplications,nutrition indicators in the corresponding period and average ICU duration was compared. Results: Patients could achieve the target amount of enteral nutrition in both groups over time. Compared to the control group,the studygroup was associated with earlier achievement of target amount of nutrition( P < 0. 05),lower feedingassociated complications( P< 0. 05),betternutritionalmarkers in the corresponding period( P < 0. 05) and shorter average ICU hospital stay( P > 0. 05). Conclusion: The sequential enteral nutrition therapy in severe acute pancreatitis could offer better tolerance,and improve the patient’s nutritional status faster.更多还原