【摘要】 目的:系统评价补充n-3多不饱和脂肪酸(PUFA)的营养支持对消化系统肿瘤病人临床结局的影响以及安全性评估。方法:文献检索数据库选择MEDLINE、EMBASE、Cochrane对照试验中心数据库(CENTRAL),(CNKI)、中国生物医学数据库(CBM)。检索起止时间为数据库默认时间。检索主题词选择Omega-3 fatty acids,fish oil,cancer,turmor,neoplasms,n-3多不饱和脂肪酸,鱼油,癌症,恶性肿瘤。按照纳入与排除标准筛选出高质量随机对照试验。采用Cochrane协作网提供的Rev Man 5.2统计软件进行分析。结果:本研究通过严格的质量控制,最终纳入585例病人11项高质量随机对照试验,来自5个不同国家不同种族。大部分临床结局分析指标与安全性评估指标合并后异质性较低,漏斗图对称,说明各研究间偏倚小,合并结果可信度高。Meta分析结果显示,补充n-3 PUFA组病人的总住院天数短于对照组,肝功能指标好于对照组,但感染等并发症以及肾功能指标两组间无统计学差异。结论:n-3 PUFA可改善消化系统肿瘤病人的某些指标,且安全性良好。更多还原

【Abstract】 Objective: To systematically review the effect on clinical outcomes and safety of n-3polyunsaturated fatty acids supplementation in digestive system cancer patients. Methods: Databases of MEDLINE,EMBASE, Cochrance Central register of controlled trials, CNKI and CBM had been searched. The descriptors were Omega-3 fatty acids,fish oil,cancer,turmor and neoplasms. According to the inclusion criteria,all high quality RCT trials were included. Rev Man 5. 2 was used for statistical analysis. Results: Eleven high-quality randomized controlled trials were included. Most indicators of clinical outcome analysis and safety assessment had small bias,the funnel figure was symmetrical,and credibility was higher. Meta-analysis results showed that the total hospital days,ALT and AST in the supplement group were lower than in the control group,and the differences were statistically significant.But there were no statistical differences in complications such as infection,BUN,Cr. Conclusion:The n-3 polyunsaturated fatty acids is effective and safe for digestive system cancer patients.更多还原