【摘要】 目的探讨MRI评估肝癌介入治疗肝储备功能及预后的临床价值。方法选取我院收治的原发性肝癌患者49例,患者术前均行MRI常规+增强序列扫描,并统计患者灶周ADC值等。统计介入治疗前后患者ICGR15、Child-Pugh评分情况。结果病灶位于肝左叶22例,肝右叶27例。介入治疗后3d、5d、7d和14d患者ICGR15和Child-Pugh评分均低于治疗前,差异有统计学意义(P<0.05)。患者复发率、转移率分别为44.90%和48.98%且发生复发和转移患者的ADC值均低于无复发和转移患者,ICGR15则高于无复发和转移患者(P<0.05)。Spearman秩相关分析结果显示,肝癌介入治疗MRI检测所得灶周ADC值与其ICGR15、Child-Pugh评分、复发率和转移率呈负相关(r=-0.763,-0.743,-0.685,-0.783,P<0.05)。结论我们发现原发性肝癌灶周MRI-ADC值越低,患者灶周肝实质肝硬化/肝纤维化越重,肝癌复发、转移率就越高,预后就越差。因此,MRI-ADC值检测结果对肝癌介入治疗肝储备和预后的评估具有一定的价值。更多还原

【Abstract】 Objective To explore the value of MRI assessing liver reserve function and prognosis of liver cancer patients treated with interventional treatment. Methods 49 primary liver cancer patients in our hospital were randomly selected. Magnetic resonance imaging(MRI) scan was finished before the treatment and ADC value was statistically analyzed and MRI imaging features of primary liver cancer was observed. ADC value,indocyanine green 15 min retention rate(ICGR15) and Child-Pugh score before and after interventional therapy and patients’ prognosis were statistically analyzed. Resultsthe lesions located in the left hepatic lobe of 22 cases, and right liver lobe of 27 cases. Child-Pugh score and ICGR15 of 3d, 5d, 7d and 14 d after interventional treatment was lower than that of before treatment, and the difference was statistically significant(P<0.05). Metastasis and recurrence rate of patients were 44.90% and 48.98% respectively. Patients with metastasis and recurrence had lower ADC value and higher Child-Pugh score and ICGR15 than that of Patients without metastasis and recurrence(P<0.05). Spearman relation analysis results showed MRI detected ADC value of patients with primary liver cancer were all negatively connected with hild-Pugh score and ICGR15, recurrence rate and metastasis rate(r=-0.763,-0.743,-0.685,-0.783, P<0.05). Conclusion MRI tested ADC value in patients with primary liver cancer is lower and connected with liver reserve function and prognosis of patients, thus value tested by MRI assessing liver reserve function and prognosis of liver cancer patients treated with interventional treatment is good.更多还原