【摘要】 目的探讨血脂异常与IgA肾病临床及病理的关系。方法收集自2008年1月至2015年11月肾活检诊断为IgA肾病患者178例。分别使用Lee氏分级及牛津分级对IgA肾病患者进行病理分级。分别探讨血脂异常、高三酰甘油血症、高胆固醇血症与IgA肾病临床及病理之间的关系。结果 IgA肾病伴血脂异常尤其是伴高三酰甘油血症者,24h尿蛋白定量升高,有较高的血肌酐和较低的eGFR。IgA肾病伴血脂异常尤其是伴高三酰甘油血症者,肾小管萎缩和(或)间质纤维化者比例高(58.5%)。结论应加强对IgA肾病患者血脂异常的认识,积极地降脂治疗,延缓IgA肾病的进展。更多还原

【Abstract】 Objective To explore the relationship between dyslipidemia with clinic and pathological features in IgA nephropathy.Methods A total of 178 IgA nephropathy diagnosed by biopsy from January 2008 to November 2015 were collected.According to Lee′s classification and Oxford classification,these patients were performed the pathological grades of IgA nephropathy.The relationship among dyslipidemia,hypertriglyceridemia,hypercholesterolemia and the clinical and pathological features of IgA nephropathy was respectively investigated.Results The patients with IgA nephropathy complicating dyslipidemia,particularly hypertriglyceridemia,had higher 24-h urine protein,higher serum creatinine and lower eGFR.The patients with IgA nephropathy complicating dyslipidemia,especially hypertriglyceridemia,had the higher proportion of renal tubular atrophy and/or interstitial fibrosis(58.5%).Conclusion The understanding of dyslipidemia in the patients with IgA nephropathy should be strengthened,lipid-lowering treatment should be actively conducted to delay the progress of IgA nephropathy.更多还原