【摘要】 目的探讨经鼻持续气道正压通气(nCPAP)干预治疗对非急性期脑梗死(CI)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者神经功能的影响。方法 68例患者经头颅CT或MRI确诊为CI且处于非急性期后,经多导睡眠图(PSG)诊断为OSAHS,将其分为观察组和对照组,对照组给予神经内科常规治疗,观察组在对照组基础上给予每晚大于4h的nCPAP呼吸机治疗,分别于治疗后1、3、6个月时根据美国国立卫生研究院卒中量表(NIHSS)对患者进行神经功能评分,爱泼沃斯嗜睡量表(ESS)进行嗜睡评分及用标准吞咽功能评定量表(SSA)进行吞咽功能评分。结果 nCPAP呼吸机治疗的观察组ESS评分下降,NIHSS评分上升,与对照组比较差异有统计学意义(P<0.05);而SSA评分与对照组比较差异无统计学意义(P>0.05)。结论nCPAP治疗可有效改善非急性期CI合并OSAHS患者症状,使其神经功能恢复,是临床一种药物以外的有效方法。更多还原

【Abstract】 Objective To investigate the influence of nasal continuous positive airway pressure(nCPAP)interventional treatment on the neural function in the patients with non-acute stage of cerebral infarction(CI)complicating obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 68 patients with non-acute stage of CI diagnosed by CT or MRI and OSAHS by polysomnography(PSG)were divided into the observation group and the control group.The control group was given the conventional neurological treatment,while on this basis the observation group was given nCPAP for over 4hat every night.The neural function was evaluated in 1,3,6months by the National Institutes of Health Stroke Scale(NIHSS),the drowsiness was evaluated by Epworth sleepiness scale(ESS)and the swallowing function was evaluated by the standard swallowing function scale(SSA).Results Compared with the control group,the ESS score in the observation group treated by nCPAP was decreased,while the NIHSS score was increased,the differences were statistically significant(P<0.05);but the SSA score had no statistically significant difference between the control group and the observation group(P>0.05).Conclusion The nCPAP treatment can effectively improve the symptoms and makes the neural function to recover in the patients with non-acute stage of CI complicating,which is an effective method besides medication.更多还原