【摘要】 纳米二氧化硅（nSiO₂）微球因其比表面积大、表面吸附力强、其表面富含可供改性的化学官能团,并且稳定性高,目前已经广泛用于模板化包药、药物运载、药物缓释等领域。以磁性Fe₃O₄为核,采用共沉淀法制备出有核壳结构的磁性纳米二氧化硅（nMSiO₂）微球,在药物传输以及荧光标记诊断方面可以实现磁导向,具有潜在的应用价值。在nMSiO2微球上接枝可以发荧光的异硫氰酸（FITC）,可以实现磁引导的同时示踪。获得的nMSiO₂微球利用磁性测试、X射线衍射（XRD）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和红外光谱（FTIR）进行结构和性能的表征,结果表明,nSiO₂微球包裹了磁性Fe₃O₄后,nMSiO₂微球具备磁性,且其性能与纯nSiO₂有了本质的差异,接枝异硫氰酸且能够发出荧光。更多还原

【Abstract】 For silicon dioxide nanospheres have large superficial area and high adsorption capacity and stability with active organic groups on the surface,they are used as templated packages medicine,drug delivery system and drug sustained release. Here,Fe₃O₄ was used as core to prepare nanosilica with core and shell structure by coprecipitation method to perform magnetic steering,especially used in the field of drug delivery system and fluorescence labeling diagnose.Isothiocyanic acid was grafted on the surface of magnetic nanosilica sphere to produce fluorescence to achieve tracer function accompany with magnetic steering. The magnetic nanosilica spheres were characterized by magnetic test,X ray diffraction,scanning electron microscope,transmission electron microscopy and infrared spectroscopic analysis. The results indicated that when Fe₃O₄ was encapsulated with silicon dioxide,the magnetic spheres have magnetism different from silica sphere,and grafting with fluorescein isothiocyanate made the spheres had the abilities to fluoresce.更多还原