【摘要】 目的:探讨钙结合蛋白S100A9(calcium binding protein A9,S100A9)和EZRIN蛋白在宫颈癌组织中的表达及其临床意义。方法:采用免疫组化法检测70例宫颈癌组织及70例正常宫颈组织中S100A9和EZRIN蛋白的表达并分析其相关性。结果:S100A9和EZRIN蛋白在宫颈癌组织中的表达均高于正常宫颈组织(P<0.05),S100A9与EZRIN蛋白在宫颈癌组织中的表达与年龄无关(P>0.05),与浸润深度及淋巴结转移有关(P<0.05);S100A9蛋白在宫颈癌组织中的表达与分化程度无关(P>0.05),EZRIN蛋白在宫颈癌组织中的表达与分化程度有关(P<0.05);S100A9与EZRIN蛋白的表达成正相关(r_s=0.136,P<0.05)。结论:S100A9和EZRIN蛋白与宫颈癌的侵袭性有关,可能成为临床判断宫颈癌预后的标志物。更多还原

【Abstract】 Objective: To investigate the expressions of calcium binding protein A9( S100A9) and EZRIN protein in cervical carcinoma and their clinical significances. Methods: Immunohistochemistry was adopted to test the expressions of S100A9 and EZRIN protein in 70 cases of cervical carcinoma and 70 cases of normal cervical epithelium and their correlation was analyzed. Results: The expressions of S100A9 and EZRIN protein in cervical carcinoma tissues were higher than those in the normal cervical epithelium( P < 0. 05). Their expressions had no relationship with age( P > 0. 05),but were closely associated with the depth of cancer invasion and lymphatic metastasis( P < 0. 05). The expression of S100A9 protein had no relationship with degrees of differentiation( P > 0. 05),but EZRIN protein expression was closely correlated with the degrees( P< 0. 05). The expressions of S100A9 and EZRIN protein were positively correlated( rs = 0. 136,P < 0. 05). Conclusion: The expressions of S100A9 and EZRIN protein may be closely related to the invasion of cervical carcinoma and can be used as clinical prognostic indicator.更多还原