【摘要】 目的研究癌性抑制因子2A(CIP2A)、转化生长因子β1(TFF—β1)在脑神经胶质瘤的表达及意义。方法选取2012年3月至2013年10月我院收治的30例脑神经胶质瘤患者,采用免疫组化法测定患者CIP2A及TFF—β1的表达,另选取正常脑组织30例作为对照组,观察两组患者各项指标的差异,并分析其临床意义。结果观察组患者TGF-β1、CIP2A阳性率均显著高于对照组,且随着肿瘤分级的提高,患者阳性表达率也随之提高,差异有明显的统计学差异(P<0.05)。结论在脑神经胶质瘤患者肿瘤组织中,TGF—β1、CIP2A表现为大幅升高,而这两个指标不在正常人脑组织中表达,对这两种指标的检测,对脑神经胶质瘤病情的评估有重要的意义。更多还原

【Abstract】 Objective To investigate the expression and clinical significance of Cancerous inhibitor of protein phosphatase 2A(CIP2A) and transforming growth factor beta 1(TGF-β1) in glioma.Methods From March2012 to October 2013,30 patients with cerebral glioma and 30 cases of normal brain tissue,as the control group were selected.The expression of CIP2 A and TGF-β1 was determined by immunohistochemistry.The clinical significance of two groups were observed.Results The positive rate of CIP2 A and TGF-β1 in the observation group were significantly higher than those in the control group,and the positive expression rate increased with higher tumor grading,the difference was statistically significant,P <0.05.Conclusion CIP2 A and TGF-β1 were expressed in tumor tissues of brain glioma,but these two proteins were not detactable in normal brain tissues,and the detection of these two markers provides significant value in the assessment of brain glioma.更多还原