【摘要】 目的:探讨血清胃蛋白酶原(PG)Ⅰ、Ⅱ对老年慢性胃炎的筛查意义。方法:选择经胃镜和病理学检查诊断为慢性胃炎的患者98例,其中老年组(≥70岁)52例,中青年组(20~60岁)46例,分别对2组患者进行血清PGⅠ、PGⅡ检测,计算PGR(PGⅠ/PGⅡ)值。结果:2组中慢性萎缩性胃炎患者的PGⅠ水平和PGR均明显低于慢性非萎缩性胃炎患者(P<0.01);老年组患者中慢性萎缩性胃炎患者的PGⅠ水平和PGR均显著低于中青年组(P<0.01);老年组慢性萎缩性患者的ROC曲线图中,PGⅠ的临界值为98.06μg/L,灵敏度和特异度分别为0.812和0.858;PGR的临界值为6.68,灵敏度和特异度分别为0.758和0.810。结论:检测血清PGⅠ、Ⅱ对于筛查老年慢性萎缩性胃炎患者具有重要意义,需要进一步确定其参考范围。更多还原

【Abstract】 Objective: To explore the screening significance of serum pepsinogenⅠ and Ⅱ( PG Ⅰ and PG Ⅱ) in elderly patients with chronic gastritis. Methods: Ninety-eight elderly patients with chronic gastritis diagnosed by gastroscopy and pathology were divided into the elderly group( 52 cases,over 70 years old) and young and middle-aged group( 46 cases,20 to 60 years old). The serum levels of PG Ⅰ and PG Ⅱ in two groups were measured,and the value of PGR( PGⅠ / PGⅡ) was calculated. Results: The levels of the PGⅠand PGR in patients with chronic atrophic gastritis were significantly lower than those in patients with chronic non-atrophic gastritis in two groups( P < 0. 01). The levels of the PGⅠand PGR in the elderly group were significantly lower than those in young and middleaged group( P < 0. 01). The ROC curve of the chronic atrophic patients in elderly group showed that the critical value of PG Ⅰ,sensitivity and specificity were 98. 06 μg / L,0. 812 and 0. 858,respectively,and the critical value of PGR,sensitivity and specificity were 6. 68 μg / L,0. 758 and 0. 810,respectively. Conclusions: The detection of serum pepsinogen Ⅰ and Ⅱ has important clinic significance in screening elderly patients with chronic atrophic gastritis,which need to further define its reference range.更多还原