【摘要】 目的探讨2型糖尿病与肺癌的关系。方法选取原发性肺癌患者合并2型糖尿病者34例为糖尿病组(DM组),同时选取2型糖尿病患者100例为对照组,对两组患者相关资料进行分析。结果 DM组患者糖尿病发病年龄为(61.02±8.74)岁,大于对照组的(56.28±9.41)岁(P﹤0.05);与糖尿病病程﹤2年比较,糖尿病病程在2~5年和﹥5年患者罹患肺癌的OR值分别为1.957和0.574,差异无统计学意义(P﹥0.05);DM组空腹血糖(FBG)和血清总胆固醇(TC)分别为(8.21±1.32)mmol/L和(5.13±1.02)mmol/L,高于对照组(P﹤0.05);DM组体质量指数(BMI)为(23.01±3.12)kg/m2,低于对照组(P﹤0.05);DM组糖尿病家族史比例为14.71%,高于对照组(P﹤0.05);多因素Logistic回归分析显示糖尿病发病年龄、糖尿病家族史与肺癌发病相关(OR=1.042和1.223,P﹤0.05)。结论在2型糖尿病患者中,罹患糖尿病的年龄越大、伴有糖尿病家族的患者肺癌的患病率有可能增加。更多还原

【Abstract】 Objective To investigate the correlation between type 2 diabetes mellitus(T2DM) and lung cancer. Meth Method 34 patients with primary lung cancer and T2DM were included in the study as DM group, while at the same time, another 100 patients with T2DM were enrolled as control group, the relevant profile of both groups were analyzed. Result The age of onset of T2DM in DM group was(61.02±8.74) years old, and was higher than that of control group at(56.28±9.41) years old(P<0.05); Compared with patients with T2 DM duration < 2 years, the OR for those who had duration of diabetes in 2-5 years and > 5 years that had developed lung cancer were 1.957 and 0.574, respectively, but there were no statistically significant differences(P>0.05); The fasting blood glucose(FBG) and serum total cholesterol(TC) in DM group were(8.21 ± 1.32) mmol/L and(5.13 ± 1.02) mmol/L, respectively, and were higher than that in control group(P<0.05); BMI in the DM group was(23.01 ± 3.12) kg/m2, and was lower than that of the control group(P<0.05); In DM group, 14.71% of patients had family history of diabetes, which was significantly more than that of control group(P<0.05); Multivariate Logistic regression analysis showed that age of onset of diabetes, family history of diabetes were associated with the incidence of lung cancer(OR=1.042 and 1.223, respectively, all P<0.05). Conclusion In patients with type 2 mellitus diabetes, lung cancer risk increases as patients had greater age of onset, and with family history of diabetes.更多还原