【摘要】 目的:研究经皮穴位电刺激(TEAS)对正畸牙痛家兔牙龈痛阈变化率、血清白细胞介索-6(IL-6)和脑脊液中5-羟色胺(5-HT)含量的影响及其疗效和可能机制。方法:24只雄性家兔按体重随机分为空白正常组、正畸模型组和TEAS组各8只,正畸模型组、TEAS组家兔建立口腔正畸实验模型,TEAS组造模后即采用疏密波治疗双侧合谷和双侧上颌第一磨牙体表对应点阿是穴,观察三组切牙牙龈局部痛阈变化率、血清IL-6和脑脊液5-HT含量。结果:正畸模型组家兔痛闽变化率明显低于空白组(P<0.01),TEAS组痛阈变化率明显低于正畸模型组(P<0.05):正畸模型组血清IL-6的合成释放明显高于空白组(P<0.05),TEAS组脑脊液5-HT合成释放量显著高于正畸模型组(P<0.01)。结论:TEAS能提高正畸牙痛动物痛阈,提高脑脊液5-HT含量可能是TEAS防治正畸牙痛的机制之一。更多还原

【Abstract】 Objective:To study the effect of transcutaneous electrical acupoint stimulation(TEAS) on the change rate of gingival pain threshold,content of serum interleukin-6(IL-6) and 5-hydroxytryptamine(5-HT) in cerebrospinal fluid and its efficacy and possible mechniam.Methods:24 male rabbits were randomly divided into blank group orthodontic model group and TEAS group according to their weight,which had 8 rabbits in each group,established orthodontic experimental models with rabbits in orthodontic model group and TEAS group,while TEAS group immediately treated with dilatational wave at both side of Hegu and the Ashi points of surface correspondence point of maxillary first molar,observed the change rate of gingival pain threshold of incisor and the content of serum IL-6 and 5-HT in cerebrospinal fluid.Results:The change rate of pain threshold of orthodontic model group was significantly lower than that of blank group(F<0.01),while that of TEAS group was significantly lower than orthodontic model group(P<0.05);the synthetic release of serum IL-6 of orthodontic model group was significantly higher than that of blank group(P<0.05),while the synthetic release of 5-HT in cerebrospinal fluid of TEAS group was significantly higher than that of orthodontic model group(P<0.01).Conclusion:TEAS can increase the pain threshold of animals with orthodontic toothache,and the increasing of the content of 5-HT in cerebrospinal fluid maybe one of the mechanisms in prevent and treatment of orthodontic toothache with TEAS.更多还原