OBJECTIVE:To evaluate the toxicity and safety of tobacco seed oil in mice.METHODS:Mice were orally exposed to tobacco seed oil for 14 and 30 days according to Care Food Inspection and Evaluation of Technical Specifications.Three genetic toxicology tests were used to evaluate mutagenic effects.In addition thirty day feeding test was conducted to detect sub-chronic toxicity.RESULTS:There was no evidence of toxicity or death in mice within 14 day,which indicated the median lethal dose(LD_(50) was more than 21 ...