【摘要】 目的观察解郁胶囊联合帕罗西汀片治疗抑郁症的临床疗效及安全性。方法将100例抑郁症患者随机分为治疗组和对照组各50例,两组最终各完成研究49例。治疗组给予口服解郁胶囊(每次4粒,每日3次)和帕罗西汀片(每次20 mg,每日1次),对照组仅给予口服帕罗西汀片,两组疗程均为6周。比较两组汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表(CGI)[包括病情严重程度(SI)、疗效总评(GI)及疗效指数(EI)]、临床疗效及不良反应。结果两组治疗2、4、6周HAMD总分、HAMA总分及SI评分与治疗前比较明显降低(P<0.01)。治疗组HAMD总分、GI评分及EI治疗第2、4、6周均低于同时间点对照组(P<0.05或P<0.01)。治疗组HAMA总分、SI评分治疗2、6周均低于同时间点对照组(P<0.05或P<0.01)。两组HAMD各因子评分治疗后不同时间分别与本组治疗前比较均明显降低(P<0.05或P<0.01)。治疗2周,治疗组焦虑、体重、睡眠障碍、绝望各因子评分均明显低于对照组(P<0.05或P<0.01);治疗4周,治疗组日夜因子评分低于对照组(P<0.01);治疗6周,治疗组焦虑、认知、阻滞、绝望障碍各因子评分均明显低于对照组(P<0.05或P<0.01)。两组临床疗效比较治疗组优于对照组(P<0.01)。结论解郁胶囊联合帕罗西汀片治疗抑郁症能明显提高临床疗效,且不良事件较单纯西药低。更多还原

【Abstract】 Objective To observe the clinical effect and safety of Jieyu Jiaonang combined with paroxetine tablets on depression. Methods Totally 100 depression patients were randomly divided into treatment group and control group with 50 cases in each group. At last,there were respectively 49 cases accomplished the trial in both groups. Treatment group was given Jieyu Jiaonang 4 capsules each time,3 times each day and paroxetine tablets 20 mg each time,1 time each day orally,and the control group was given paroxetine tablets only,for 6 weeks. Compare Hamilton Depression Scale( HAMD),Hamilton Anxiety Scale( HAMA),Clinical Global Impression Scale( CGI)including severity of illness( SI),global improvement( GI) and efficacy index( EI),clinical effect and adverse reactions. Results After 2,4,6 weeks,total scores of HAMD,HAMA and SI in both groups decreased obviously( P < 0. 01). Total scores of HAMD,GI and EI of treatment group were lower than those of control group at the same time point( P < 0. 05 or P < 0. 01). Total scores of HAMA and SI of treatment group were lower than that of control group at the same time point( 2nd,6th week,P < 0. 05 or P < 0. 01). After treatment,all factors’ scores in HAMD of both groups decreased significantly at different time( P < 0. 05 or P < 0. 01). After 2 weeks,factors’ scores of anxiety,weight,sleep disorder and despair of treatment group were lower than that of control group( P < 0. 05 or P <0. 01). After 4 weeks,the factor score of feeling in morning or evening was lower than that of control group( P <0. 01). After 6 weeks,factors’ scores of anxiety,cognition,retardation and despair were lower than that of control group( P < 0. 05 or P < 0. 01). The clinical effect of treatment group was superior to control group( P < 0. 01).Conclusion Jieyu Jiaonang combined with paroxetine tablets could improve clinical effect in depression,with less adverse reactions than Western medicine alone.更多还原