【摘要】 能量过剩已经成为日益严峻的危害我国人群健康的主因。过剩的能量以甘油三酯的形式主要在肝脏、也可在胰腺等器官异位沉积,产生慢性氧化和硝基化应激(ONS)及脂毒性,导致胰岛素抵抗和胰岛功能受损,进而出现糖调节受损(脾瘅)。结合中医病因病机及证候分析,此一过程具有"肝病传脾"的特点。依据多项相关指南和临床实践,论证了痰瘀同治法是干预代谢病肝病传脾的治法。此思路有助于将主要代谢性疾病——非酒精性脂肪性肝病(NAFLD)和2型糖尿病的防治有机整合,提高中医药的临床效果和效率。更多还原

【Abstract】 Excess energy has become a main reason for increasingly serious human health hazards.Excess energy,mainly ectopically deposits in the liver,pancreas and other organs in the form of triglycerides,and produces chronic oxidative,nitrosative stress(ONS),and fat toxicity,resulting in insulin resistance and impaired insulin secretion,and further impaired glucose regulation(Pidan).By combining Chinese medical pathogeneses and symptoms analyses,authors found this process has features of Gan disease transferring to Pi.Based on a number of related guidelines and clinical practice,we demonstrated treating sputum and stasis by the same method was one treatment method for intervening liver disease transferring to spleen in metabolic diseases.This idea helps to organic integrating prevention and treatment of major metabolic diseases including non-alcoholic fatty liver disease(NAFLD) and type 2 diabetes mellitus,which can improve clinical effectiveness and efficiency of Chinese medicine.更多还原