【摘要】 目的探讨上巨虚与大肠相关的可能机制。方法选用SD大鼠40只,采用末段结肠扩张作为伤害性结肠传入刺激,应用微电极细胞外记录蓝斑核(LC)神经元活动。针刺大肠下合穴上巨虚和大肠经合穴合谷,观察LC神经元放电反应的一般特性、结肠扩张刺激诱发LC神经元放电反应及针刺上巨虚、曲池对结肠扩张刺激诱发LC神经元放电反应的影响。结果结肠扩张可以诱发LC神经元放电增加,增加率为127.33%±45.48%,针刺上巨虚和合谷均能抑制这种伤害性反应,抑制率分别为38.24%±7.69%和21.29%±13.16%,差异有统计学意义(P<0.01)。结论针刺上巨虚和结肠伤害性传入信号在LC神经元发生会聚和相互作用,针刺上巨虚能显著抑制结肠扩张激活的LC神经元放电,可能是上巨虚和大肠相关的机制之一。更多还原

【Abstract】 Objective To study possible mechanisms of Shangjuxu( ST37) and the large intestine. Methods Totally 40 SD rats were selected. The distension of end colon was used as injured afferent stimulus. Activities of locus coeruleus( LC) neurons were recorded by extracellular microelectrode technique. Shangjuxu( ST37) and Hegu( LI4) were needled to observe general features of discharge reactions,distention of colon induced discharge reactions of LC,and its effects on distention of colon induced discharge reactions of LC. Results Distention of colon could induce incrased discharge of LC neurons by 127. 33% ± 45. 48%. But needling at Shangjuxu( ST37) and Hegu( LI4) could inhibit this injured response by38. 24% ± 7. 69% and 21. 29% ± 13. 16% respectively( all P < 0. 01). Conclusions Needling at Shangjuxu( ST37)and afferent signals of colon distension converged and interacted with each other. Needling at Shangjuxu( ST37) could significantly inhibit colon distension induced discharge of LC neurons,which might be one of mechanisms for Shangjuxu( ST37)and the large intestine relationship.更多还原