【摘要】 目的分别采用Excel和CMRtools(2012)软件计算重型β地中海贫血患者的T2*值,探讨两者评价铁过载患者T2*值的一致性和可替代性。资料与方法将27例重型β地中海贫血患者的T2*图像直接导入CMRtools(2012),在图像上勾画感兴趣区,去除干扰信号后直接计算出T2*值;在MRI自带软件中测量T2*图像感兴趣区的信号值,手工输入Excel中,去除干扰信号后计算出T2*值,比较两种方法测量肝脏及心肌铁过载T2*值的差异。结果 27例重型β地中海贫血患者中,心肌铁过载10例,肝脏铁过载25例。Excel和CMRtools(2012)软件计算的心肌及肝脏T2*值差异无统计学意义(t=-0.152、-0.691,P>0.05)。结论 Excel和CMRtools(2012)软件在评价铁过载患者的T2*值方面具有很好的一致性,临床上可以应用Excel评价重型β地中海贫血患者的铁过载情况。更多还原

【Abstract】 Purpose To assess the level of agreement and interchangeability among Excel and CMRtools(2012) for calculation of T2* values in iron overload. Materials and Methods T2* images in 27 cases with β-thalassemia major were imported into CMRtools(2012). The regions of interest(ROI) were drawn and interference signal removed to obtain T2* values. The T2* images were also measured using default MR software and manually entered into Excel to obtain T2* values after removal of the interference signal. The agreement between the two methods in calculating T2* values was compared. Results For 27 patients with β-thalassemia major,10 cases showed myocardial iron overload. 25 cases had liver iron overload. The T2* values from two methods were not statistically significant(t=- 0.152 and- 0.691,P>0.05) for the liver. Conclusion There is good agreement and interchangeability between Excel and CMRtools(2012) in calculating T2*values. Excel can be used clinically to evaluate iron overload.更多还原