【摘要】 目的观察正常妊娠妇女体内甲状腺过氧化物酶抗体(TPOAb)水平,以及与促甲状腺激素(TSH)水平变化之间的关系,并探讨其在产前筛查的价值。方法选取463例孕妇(孕周12~24周),采用化学发光法(CIA)检测促甲状腺激素(TSH)和甲状腺过氧化物酶抗体(TPOAb)水平,以TPOAb值<9IU/ml为正常范围,根据TPOAb测定结果,将463例孕妇分为阳性组53例,和阴性组410例。结果 53例TPOAb阳性的孕妇,其中有5例TSH异常(9.43%),410例TPOAb阴性的孕妇,其中12例TSH异常(2.92%),其异常率有统计学意义(P<0.05)。结论 TPO阳性孕妇甲状腺功能紊乱明显增加,TPOAb阳性孕妇的甲状腺功能有向亚临床甲状腺功能减退的趋势。更多还原

【Abstract】 Objective:This study amied to observe the level of the thyroid peroxidase antibody(TPOAb)and the thyroid stimulating hormone(TSH)and how TPOAb affects thyroid function in healthy pregnant women,and then to research its value in trimester screening. Methods:The level of TPOAb and TSH were measured by chemiluminescence(CIA)of 463 gravidas(between 12 and 24 weeks,gestation)which were divided into positive group and negative group with the cuoff value <9IU/ml in TPOAb. Results:5 women whose TSH was abnormal within 53 cases TPOAb-positive group(9.43%),compared with 12 women whose TSH was abnorma cases within the 410 cases TPOAb-negative group(2.92%),the abnormal rates were significantly different(P<0.05). Conclution:Pregnant TPOAb positive women are more likely to suffer from markedly increased TSH levels,with increased risk being subclinical hypothyroidism.更多还原