【摘要】 目的探讨早期自然流产患者胎盘绒毛滋养细胞中Fas、Survivin、Ki-67的表达及意义。方法采用免疫组化Max Vision法检测Fas、Survivin和Ki-67在48例早期自然流产和25例早期正常妊娠(作为对照组)妇女的胎盘绒毛滋养细胞中的表达。结果自然流产组中Fas强阳性表达高于对照组(P<0.05),而Survivin和Ki-67则明显低于正常组,差异有统计学意义(P<0.01)。结论胎盘绒毛滋养细胞中Fas表达上调或Survivin和Ki-67表达下调可能是引起早期自然流产的重要原因。更多还原

【Abstract】 Objective:To investigate the expression and the significance of Fas and Survivin and Ki-67 in placenta villi nutrient cells of patients with early spontaneous abortion. Methods:The expression of Fas and Survivin and Ki-67 in placenta villi nutrient cells of 48 patients with early abortion and 25 early normal pregnancy(as the control group)were detected by immunohistochemistry. Results:The expression of Fas strong positive in early spontaneous abortion group was higher than the control group(P<0.05),and Survivin and Ki-67 is significantly lower than normal group. The difference was statistically significant(P<0.01). Conclusions:The expression of Fas was rised or the expression of Survivin and Ki-67 were reduced in placenta villi nutrient cells may be an important cause of early spontaneous abortion.更多还原