【摘要】 目的探讨羊水细胞染色体核型分析在产前诊断中的应用。方法对86例妊娠16-24周符合产前诊断指征的孕妇经知情同意后,在B超引导下行羊膜腔穿刺术,抽取羊水30ml,进行羊水细胞培养、制片、常规G显带,分析染色体核型。结果 86例孕妇羊水细胞培养成功85例,成功率为98.8%,发现异常核型8例,其中染色体数目异常6例,遗传多态性2例。结论羊水细胞核型分析在产前诊断中可避免染色体患病胎儿的出生,对高危妊娠妇女进行羊水染色体核型检查是非常必要的。更多还原

【Abstract】 Objective:To explore the application of amniotic cell karyotype analysis for prenatal diagnosis. Methods:Amniotic fluid of 16-24 pregnant weeks women were draw via ultrasound-monitored amniocentesis through imformed consent,amniotic cell were cultured and harvested for G-band karyotype analysis. Results:The success rate of amniotic cell culture was 98.8%(85/86). 8 cases were founded,which includes 6 cases of abnormal number of chromosome and 2 cases of chromosome polymorphism. Conclusion:Analysis on karyotype of amniotic fluid cells can avoid the birth of the fetus chromosome abnormality,it is necessary for high risk gravida.更多还原