【摘要】 目的采用Meta分析评价黑质磁敏感加权成像(SWI)对帕金森病(PD)的临床诊断价值。方法对Web of Science、PubMed、中国生物医学文献数据库等数据库中公开发表的有关SWI诊断PD的文献进行评价和筛选,采用RevMan5.3、Stata11.2统计软件检验异质性。根据异质性结果选择相应效应模型,计算总体效应值及其95%可信区间(95%CI),最后进行敏感度和漏斗图分析。结果共收集到符合纳入标准文献9篇,累计正常对照组389名,病例组355例。PD组与正常对照组的黑质相位值总体效应检验[Z=1.11,P=0.27,95%CI(-0.05,0.11)]、黑质网状带相位值总体效应检验[Z=1.82,P=0.07,95%CI(-0.00,0.01)]差异无统计学意义,黑质致密带相位值总体效应检验[Z=27.88,P<0.00001,95%CI(-0.06,-0.05)对诊断PD有统计学意义。漏斗图分布呈倒漏斗形,近似对称;Begg’s检验、Egger’s检验证实发表无偏倚;敏感度分析结果可靠。结论 Meta分析提示SWI测量黑质致密带相位值有助于诊断PD。更多还原

【Abstract】 Objective To evaluate the diagnostic value of susceptibility weighted imaging(SWI)of substantia nigra(SN)in Parkinson disease(PD)with Meta analysis.Methods The literatures about diagnosis of PD by SWI were searched in the database of Web of Science,PubMed and CNKI,etc.Statistical analysis was performed with RevMan 5.3and Stata11.2vision.The heterogeneity of including articles was tested.According to the random effects model,the overall effect value and 95%confidence interval(95%CI)were calculated.The sensitivity and publication bias were analyzed with funnel plot.Results Nine studies involved 389 normal control and 355 PD patients.The overall effect value with the phase of SN and subatantia nigra pars reticulata(SNr)in PD patients and controls was no statistical(Z=1.11,1.82,P=0.27,0.07,95%CI[-0.05,0.01],[-0.00,0.01]),the overall effect value with the phase of sustantia nigrapars compacta(SNc)between PD patients and controls was statistical significance(Z=27.88,P<0.00001,95%CI[-0.06,-0.05]).Funnel plot showed the distribution of a inverted funnel,shaped approximate symmetry.Begg’s and Egg’s test showed the publication bias was not significant(P>0.05),and the analysis of sensitivity had no significant difference.Conclusion Metaanalysis indicates that measurement of phase value of SNc on SWI is helpful for the diagnosis of PD.更多还原