The effects of biodegradable Mg-6Zn alloy on tight junction of intestinal epithelial cells(IEC-6) were investigated.In the in vitro experiments,the cells were exposed to Mg-6Zn alloy extracts with different concentrations(0,20%and 40%) for 1,3 and5 d.The real-time polymerase chain reaction(PCR) results show that when the cells are treated with 40%and 20%extracts,the expression of Zona Occludens 1(ZO-1) and Occludin increase as compared with those in the control group.In the in vivo experiments,Mg-6Zn alloy ...
【基金】
Project(30901422)supported by the National Natural Science Foundation of China;
Project(YG2010MS45)supported by Shanghai Jiao Tong University Interdisciplinary(Biomedical Engineering)Research Fund,China;
Project(09XJ21005)supported by School of Medicine Science and Technology Fund,Shanghai Jiao Tong University,China
【更新日期】
2015-12-24
【分类号】
R574;TG146.22
【正文快照】
1 IntroductionAt present,due to its good mechanical properties,metallic materials such as stainless steel,Nitinol,titanium and titanium alloys are commonly used assurgical staples and surgical suture material.The use ofthese materials can shorten the oper
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