【摘要】 目的:观察聚乙二醇干扰素α-2a治疗慢性乙型肝炎的抗病毒、抗纤维化疗效。方法:100例HBe Ag阳性的慢性乙肝患者,给予聚乙二醇干扰素α-2a 180μg,皮下注射,每周1次,疗程48周。观察其治疗12周、24周、48周时血清HBs Ag定量、HBe Ag定量、ALT复常率、HBV-DNA阴转率、瞬时肝弹性测定数值。结果:患者在治疗12周、24周、48周时血清HBs Ag定量、HBe Ag定量逐渐下降,HBV-DNA阴转率增加,ALT复常率提高,瞬时肝弹性测定数值逐渐下降,各治疗节点间比较,差异均有统计学意义(P<0.05);且HBs Ag定量、HBe Ag定量与瞬时肝弹性测定之间呈正相关,相关系数分别为0.826、0.782(P<0.05)。结论:聚乙二醇干扰素α-2a在慢性乙肝患者的抗病毒、抗纤维化治疗中,疗效确定。更多还原

【Abstract】 Objective: To observe the anti-viral and anti-fibrotic effect of pegylated interferon α-2a in the treatment of chronic hepatitis B patients. Methods: Totally 100 cases of HBe Ag-positive chronic hepatitis B patients were treated with 180μg pegylated interferon α-2a with subcutaneous injection,once a week for 48 weeks. In the 12 th,24th and 48 th week,the serum HBs Ag quantification,HBe Ag quantification,ALT normalization rate,HBV-DNA negative rate and transient liver elasticity were measured. Results: In the12 th,24th and 48 th week,the HBe Ag quantification was gradually decreased,the HBV-DNA negative rate and ALT normalization rate were both increased,and the transient liver elasticity was decreased. The differences among the time nodes were statistically significant( P < 0. 05). Moreover,the correlation coefficient between the HBs Ag or HBe Ag positive quantification and the transient liver elasticity quantification was 0. 826 and 0. 782,respectively( P < 0. 05). Conclusion: Pegylated interferon α-2a has notable anti-viral and antifibrotic efficacy in the treatment of patients with chronic hepatitis B.更多还原