【摘要】 目的:观察不同剂量中/长链脂肪乳对早产儿及低出生体质量儿生长发育的影响。方法:76例早产或低出生体质量儿随机分为观察组(40例)与对照组(36例),在出生后12~24 h内给予中/长链脂肪乳、氨基酸、葡萄糖注射液等治疗,其中观察组中/长链脂肪乳从2.0 g·kg-1·d-1始,以0.5 g·kg-1·d-1递增,逐渐增至3.0 g·kg-1·d-1;对照组中/长链脂肪乳从0.5 g·kg1·d-1始,以0.5 g·kg-1·d-1递增,逐渐增至3.0 g·kg-1·d-1。两组疗程均为7 d。监测两组新生儿体质量增长情况及治疗后血清总胆红素、直接胆红素、丙氨酸氨基转移酶、总胆固醇、三酰甘油及血糖等指标的变化。结果:观察组恢复出生体质量时间(4.38±0.93)d,明显短于对照组的(6.81±1.90)d,恢复后体质量增长幅度(30.41±1.81)g·kg-1·d-1,也明显高于对照组,差异均有统计学意义(P<0.05),两组患儿治疗7 d后血生化指标差异无统计学意义(P>0.05)。结论:早期大量应用中/长链脂肪乳有利于改善早产儿的早期营养状况。更多还原

【Abstract】 Objective: To analyze the effect of MCT / LCT fat emulsions at different doses on the growth and development of premature and low birth weight infants. Methods: Totally 76 cases of preterm or low birth weight infants were divided into the treatment group( 40 cases) and the control group( 36 cases),both groups were given MCT / LCT fat emulsions,amino acid and glucose injections in 12-24 h after the birth. The initial dose of MCT / LCT fat emulsions in the treatment group was 2. 0 g·kg- 1·d- 1and the dose was gradually increased to 3. 0 g·kg- 1·d- 1with 0. 5 g·kg- 1·d- 1progressive increase. The initial dose of MCT / LCT fat emulsions in the control group was 0. 5 g·kg- 1·d- 1,and the dose was increased to 3. 0 g·kg- 1·d- 1with 0. 5 g·kg- 1·d- 1progressive increase. The treatment course was 7 days. The neonatal weight,serum total bilirubin,direct bilirubin,alanine aminotransferase,total cholesterol,triacylglycerol and blood glucose were monitored in the two groups. Results: The born body mass recovery time of the observation group was( 4. 38 + 0. 93) d,which was significantly shorter than that in the control group [( 6. 81 + 1. 90) d]. After the recovery,the body weight growth rate of the observation group was( 30. 41 + 1. 81) g·kg- 1·d- 1,which was significantly higher than that of the control group [( 18. 21 + 2. 08) g · kg- 1·d- 1,P < 0. 05]. After the 7-day treatment,the blood biochemical indices showed no statistically significant difference between the two groups( P > 0. 05). Conclusion: Early application of MCT / LCT fat emulsions at high dose is beneficial to the improvement of nutritional status in premature infants.更多还原