【摘要】 目的观察右美托咪定对不同年龄患者顺行性遗忘作用的影响。方法选择美国麻醉医师学会(ASA)Ⅰ~Ⅱ级、年龄18~84岁,在腰硬联合麻醉下复合右美托咪定行下腹部(剖宫产术除外)手术患者120例,其中男73例,女47例。根据患者年龄的不同分为四组:A组(23±4)岁,B组(36±3)岁,C组(65±3)岁,D组(75±5)岁。所有患者均给予右美托咪定负荷量1μg/kg,泵入10 min之后以0.2μg·kg-1·h-1剂量维持。术后24 h回访患者并评定右美托咪定的顺行性遗忘作用。结果 A组和B组右美托咪定顺行性遗忘作用无明显不同(P>0.05),而C组与D组较前两组右美托咪定顺行性遗忘作用比较明显(P<0.05),并随年龄的增大明显增加(P<0.05)。结论右美托咪定具有一定的顺行性遗忘作用,且对老年患者更为明显。更多还原

【Abstract】 Objective To study the effects of dexmedetomidine on the anterograde amnesia in patients with different ages. Methods One hundred and twenty ASAⅠ ~ Ⅱ patients,age from 18 years to 84 years,73 cases of male and 47 cases of female,who were dministered spinal-epidural anesthesia combined with dexmedetomidine and performed operation on hypogastrium( except for caesarean section). All patients were randomly divided into four groups: group A,group B,group C and group D. Dexmedetomidine( 1 μg / kg) was infused intravenously for 10 min and the maintenance dose was 0. 2 μg · kg- 1·h- 1. The anterograde amnesia degree of dexmedetomidine was assessed 24 h after the operation. Results There was no significant difference in the anterograde amnesia of dexmedetomidine between group A and group B( P > 0. 05),while there were significant differences in group C and group D compared with both group A and group B( P < 0. 05). Conclusion Anterograde amnesia occurs after using dexmedetomidine in elderly patients and with aging,the anterograde amnesia becomes more severe.更多还原