【摘要】 目的探讨不同人种和宗教背景的患者痛阈和镇痛治疗效果的差异。方法选取择期在静吸复合全麻下行腹腔镜阑尾炎切除术的18至38岁男性患者48例,采用随机单位组3×2析因设计:将每例入选对象视为1个单位,对每个单位设置2个影响因素,即所在人种因素(3水平:欧罗巴人种、尼格罗人种、蒙古人种)和宗教背景因素(2水平:信仰宗教、不信仰宗教)的所有组合(共6组,n=8)。所有试验对象实施相同的麻醉、手术以及帕瑞昔布钠术后镇痛。在进行镇痛治疗前1 h和镇痛治疗后1 h,分别测量其温度痛阈和电痛阈。结果镇痛治疗前后,欧罗巴人种较尼格罗人种和蒙古人种痛阈高;有宗教信仰与无宗教信仰受试者的温度疼痛感知阈和电疼痛感知阈差异均无统计学意义(镇痛治疗前:F=251.119,P=0.130,F=275.861,P=0.059;镇痛治疗后:F=308.531,P=0.086,F=180.062,P=0.078);人种和宗教因素对温度疼痛感知阈和电疼痛感知阈也不具有交互作用(镇痛治疗前:F=13.553,P=0.091,F=22.001,P=0.089;镇痛治疗后:F=4.624,P=0.089,F=15.935,P=0.094)。结论不同人种的痛阈有一定差异,欧罗巴人种的痛阈最高,尼格罗人种次之,蒙古人种的痛阈最低。有无宗教信仰不能明显影响个体的痛阈。更多还原

【Abstract】 Objective To explore the differences of the thresholds of pain and analgesic effects of parecoxib sodium among patients with different racial and religious backgrounds. Methods A total of 48 male patients aged 18 to 38 years who had undergone elective laparoscopic appendectomy under general anesthesia in our centers were enrolled in our study and then divided into 6 groups( n = 8 in each group) based on their racialbackgrounds( three levels: Mongoloid,Negroid,and Europoid) and religious backgrounds( two levels: without religion background,with religion background). All subjects received the same anesthesia,surgical procedure,and postoperative analgesia with parecoxib sodium. The temperature pain threshold and electrical pain threshold were detected 1h before and after analgesia. Results The threshold of pain was higher in Europoids than in Negroids and Mongoloids before and after treatment. The temperature pain threshold and electrical pain threshold were not significantly different between subjects with or without religious background( before analgesic therapy: F = 251. 119,P = 0. 130, F = 275. 861, P = 0. 059; after analgesic therapy: F = 308. 531, P =0. 086,F = 180. 062,P = 0. 078). Also,there was no interaction between the racial and religious backgrous in terms of temperature pain threshold and electrical pain threshold( F = 13. 553,P = 0. 091,F = 22. 001,P =0. 089; after analgesic therapy: F = 4. 624, P = 0. 089, F = 15. 935, P = 0. 094). Conclusions The threshold of pain differs among individuals with different racial background: it is highest in Europoids,followed by Negroids and Mongoloids. It shows no obvious difference in people with different religious backgrounds.更多还原