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正交试验法优选温热清口服液提取工艺

Extraction Technology Optimization for Wenreqing Oral Liquid by Orthogonal Test

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【作者】 孙文鹏韩在虹孙瑜高明

【Author】 SUN Wenpeng;HAN Zaihong;SUN Yu;Medical College of Dalian University;Qiqihaer Hospital of Traditional Chinese Medicine,Heilongjiang Province;

【机构】 大连大学医学院黑龙江省齐齐哈尔市中医医院

【摘要】 目的优选温热清口服液的提取工艺。方法采用正交试验,以挥发油含量为指标,考察药材蒸馏时间、料液比、超声时间3因素对挥发油提取的影响;以绿原酸含量和浸膏得率为综合指标,筛选提取工艺条件。结果优选的挥发油提取工艺为蒸馏4 h,加8倍量水,超声60 min;最佳提取工艺为加12倍量水煎煮3次,煎煮时间为50 min。结论该提取工艺合理、稳定,为温热清口服液工业生产提供参考。

【Abstract】 Objective: To optimize extraction technology of Wenreqing Oral Liquid. Methods: The research had been screened out the best abstraction technological conditions of Wenreqing Oral Liquid by orthogonal test,using the weight of volatile oil to investigate the influence by the factors of distillation time,ratio of solid to liquid,ultrasonic time and so on. Chlorogentic acid content and extract yield rate were used as comprehensive indicators. Results: The optimization method of extraction technology of the volatile oil was distilling 4h with 8 times the amount of water and ultrasound for 1h. The best extracting process was decocting three times with 12 times the amount of water,and the three decocting durations were 50 minutes. Conclusion: The technology is reasonable and stable that can provide reference for industrial production.

【基金】 黑龙江省齐齐哈尔市科技局计划项目(SFGG-201344)
  • 【文献出处】 中国中医急症 ,Journal of Emergency in Traditional Chinese Medicine , 编辑部邮箱 ,2015年01期
  • 【分类号】R283.6
  • 【被引频次】1
  • 【下载频次】56
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