【摘要】 目的分析2009—2013年丹东市托幼机构手足口病(HFMD)聚集性疫情的流行病学特征及病原学监测结果,为该地区有效控制HFMD提供科学依据。方法收集2009—2013年丹东市托幼机构HFMD聚集性疫情资料,进行流行病学分析,采集托幼机构患儿发病3 d内的样本开展荧光定量PCR检测。结果 2009—2013年丹东市83起聚集性HFMD疫情均发生在托幼机构,托幼机构病例占全市总病例数的43.76%(1 196/2 733),聚集性疫情病例占托幼机构病例总数的35.62%(426/1 196);托幼机构聚集性疫情在地区间、年龄间和性别间差异均有统计学意义(χ2=31.96、18.73、23.52,P<0.01);经回归分析决定系数R2=0.64(F=173.87,P<0.01);病原学监测结果显示,聚集性病例EV71检出水平高于全市和托幼机构检出水平(χ2=26.69,P<0.01),而其他肠道病毒检出水平低于全市和托幼机构(χ2=8.14,P<0.05)。结论托幼机构是HFMD防控的重点场所,应加强与教育等部门间协作防控HFMD疫情,以减少HFMD的暴发流行。今后在托幼机构HFMD聚集性疫情调查处置过程中应继续加强病原学监测。更多还原

【Abstract】 [Objective]To analyze the epidemiological characteristics and etiological monitoring results of aggregation outbreaks of hand-foot-mouth disease(HFMD)in kindergartens of Dandong City from 2009-2013,provide a scientific basis for effective control of HFMD in this region. [Methods]The epidemic data of HFMD aggregation outbreaks in kindergartens of Dandong City from2009-2013 were analyzed epidemiologically. Meanwhile,the samples of sick child were collected within 3 days of the onset,to carry out a fluorescence quantitative PCR detection. [Results]In Dandong City,all of 83 HFMD aggregation outbreaks had occurred in kindergartens during 2009-2013,the cases in kindergartens accounted for 43.76% of total cases(1 196/2 733),and cases in aggregation outbreaks accounted for 35.62% of total cases in kindergartens(426/1 196). There were significant differences in HFMD aggregation outbreaks of kindergartens among different region,age,sex groups(χ2=31.96,18.73,23.52,P <0.01). The regression analysis showed that the coefficient R2 =0.64(F =173.87,P <0.01). The etiological monitoring results revealed that the detection rate of EV71 in aggregation cases was higher than that in kindergartens and Dandong City(χ2=26.69,P <0.01),while the detection rate of enteroviruses in aggregation cases was lower than that in kindergartens and Dandong City(χ2=8.14,P<0.05).[Conclusion]Kindergartens are the key places for the prevention and control of HFMD. It is necessary to improve the cooperation between departments to control the epidemic situation,to reduce HFMD outbreak. In the future,the etiological monitoring should be strengthened in the investigation and disposal of HFMD aggregation outbreaks in kindergartens.更多还原