【摘要】 目的:探讨氨氯地平瑞舒伐他汀钙片治疗高血压合并冠心病的临床效果以及炎症反应。方法:研究对象选取本院2013年1月-2014年1月高血压合并冠心病患者100例,按照随机抽签法分为对照组与观察组,每组50例。对照组患者采用硝苯地平治疗,观察组患者采用氨氯地平瑞舒伐他汀钙片治疗。对比两组患者治疗前后血压水平、心电图改善情况以及不良反应出现率。结果:治疗后,观察组总有效率为98.00%。优于对照组32.00%。治疗后观察组患者血管收缩压、舒张压平均值明显优于对照组且治疗总有效率明显高于对照组,比较差异具有统计学意义(P<0.05)。治疗后,两组患者hs-CRP、IL-18、C-myc、Bcl-2水平比较,差异无统计学意义(P>0.05)。结论:氨氯地平瑞舒伐他汀钙片在治疗高血压合并冠心病方面疗效确切,在有效降压、降血脂作用外,其还有抗炎、抗凋亡临床效果,值得进行临床推广应用。更多还原

【Abstract】 Objective: To investigate the amlodipine rosuvastatin calcium tablets in treatment of hypertension and coronary heart disease clinical effect and inflammatory reaction. Method: The study objects were 100 patients with hypertension and coronary heart disease in our hospital from January 2013 to January 2014, and were randomly divided into control group and observation group, 50 cases in each group. The control group was treated with nifedipine, the observation group was treated with amlodipine rosuvastatin calcium. To compare level of blood pressure, ECG improvement and adverse reaction rate between the two groups. Result: After treatment, the total effective rate of the observation group was 98.00%, which was higher than 32.00% of the control group. After treatment, coronary artery disease average systolic and diastolic blood pressure values of the observation group was better than that of the control group, the difference was statistically significant(P<0.05). After treatment, hs-CRP, IL-18, C-myc, and Bcl-2 level between the two groups had no significant difference(P>0.05). Conclusion: Amlodipine rosuvastatin calcium tablet in the treatment of hypertension and coronary heart disease curative effect, in the effective antihypertensive and hypolipidemic effect, its anti-inflammatory and anti apoptosis and clinical efficacy, is worthy of clinical application.更多还原