【摘要】 目的:探究长期应用非那雄胺治疗良性前列腺增生的临床疗效。方法:选取2007年6月-2009年8月在本院就诊的初诊良性前列腺增生症患者80例,每日服用非那雄胺5 mg,进行为期至少5年的随访,患者进行前后对照,对患者治疗前后夜尿次数、前列腺指检体积、B超检查前列腺体积、血肌酐、血白细胞数、血小板、血红蛋白、膀胱残余尿量、最大尿流率、血PSA、调整后PSA、国际前列腺症状评分进行记录和分析。结果:患者治疗后均无严重不良反应发生,且较治疗前夜尿次数、最大尿流率、国际前列腺症状评分增加,B超检查前列腺体积、血小板、血红蛋白、膀胱残余尿量、血PSA减少,差异均有统计学意义(P<0.05)。结论:非那雄胺能够减少前列腺体积,改善尿动力学功能,增加IPSS,长期应用不会出现严重不良反应,值得在临床上推广。更多还原

【Abstract】 Objective:To investigate clinical efficacy analysis of long-term use of finasteride in benign prostatic hyperplasia.Method:80 patients with BPH,who were diagnosed from June 2007 to August 2009 in our hospital were chosen.Every patient was obtained 5 mg finasteride per day,and was followed up at least 5 years.After and before control was chosen,and frequencies of nocturia,prostate volume in finger exam and B ultrasound,serum creatine,complete blood count,Ru,Qmax,PSA,adjusted PSA and IPSS were noted.Result:Serious side effects of treatment was not observed.Compared to pretreatment,frequencies of nocturia,Qmax,IPSS increased,prostate volume in B ultrasound,platelet,haemoglobin,Ru decreased,whose differences were significant(P<0.05).Conclusion:Finasteride can decrease prostate volume,improve urodynamics functions and increase IPSS,serious side effects in long-term use do not occur.So it is worthy of clinical promotion.更多还原