【摘要】 目的:探讨2型糖尿病性眼肌麻痹的临床特点,并观察使用前列地尔联合甲钴胺治疗的疗效。方法:回顾性分析2008-2014年于我院内分泌科住院的21例糖尿病性眼肌麻痹患者的临床特点和治疗情况,并进行探讨。结果:21例糖尿病眼肌麻痹患者均为单眼患病,其中动眼神经麻痹14例,外展神经麻痹7例;9例有高血压,8例有高脂血症。患者均接受前列地尔联合甲钴胺治疗2周,出院后随诊3月,痊愈13例,好转8例,痊愈组患者糖化血红蛋白更低、糖尿病病程更短。结论:糖尿病眼肌麻痹中动眼神经受累最常见,外展神经次之;病程和糖化血红蛋白是影响预后的危险因素;前列地尔联合甲钴胺治疗糖尿病眼肌麻痹安全有效。更多还原

【Abstract】 Objective: To investigate the clinical characteristics of diabetes-associated ophthalmoplegia and observe the clinical effect of combination of alprostadil and mecobalamin for this complication. Methods: A retrospective study was performed in 21 diabetic patients with ophthalmoplegia who were hospitalized in the endocrinology department of our hospital from 2008 to 2014. Results: Among the 21 patients,there were 14 patients with isolated oculomotor nerve palsy and 7 patients with isolated abducent nerve palsy. Nine of them were affected by hypertension and 8 by hyperlipidemia. All of them were given alprostadil and mecobalamin for consecutive 2 weeks. After3 months treatments,13 patients healed up and 8 cases got better. The level of glycosylated hemoglobin was lower and the duration of diabetes was shorter in the recovered patients than in those relieved. Conclusion: Isolated oculomotor nerve palsies accounts for the majority of patients with ophthalmoplegia in diabetes mellitus. The duration of diabetes and the level of glycosylated hemoglobin are risk factors of prognosis. The combimtion of alprostadil and mecobalamin is effective and safe in the treatment for diabetic ophthalmoplegia.更多还原