As the first-line treatment therapy for active mild to moderate ulcerative colitis in the last thirty years,mesalamine is efficacious in inducing and maintaining remission of ulcerative colitis patients. Only in the prototype form can mesalamine play a therapeutic role on the inflamed colonic mucosa,while conventional mesalamine formulations are rapidly absorbed by gastrointestinal tract and metabolized by liver following oral administration which remain little at the colon inflamed target site and lead to ...
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