Objective To investigate the role of GOLPH3 in esophageal squamous cell carcinoma(ESCC).Methods Wound healing assays,transwell invasion assays and 3D culture were carried out to analyze the cell migration and invasion ability of GOLPH3 overexpression and knockdown KYSE-140 cells.The relationship between GOLPH3 expression and CYR61,CD44 and Snail m RNA expression was further examined through q RT-PCR,to identify the mechanisms involved.Results GOLPH3-promoted ESCC cell migration and invasion.CYR61,CD44 and S...
【基金】
广东省自然科学基金项目资助(S2013010011548)~~
【更新日期】
2015-08-20
【分类号】
R735.1
【正文快照】
科(广州510060)王建华和袁林静为共同第一作者食管癌是发展中国家最为高发的恶性肿瘤之一,其发病率在男性恶性肿瘤中排第5,在女性中排第8。而死亡率在男性中排第4,在女性中排第7。食管癌发病率最高的地区包括我国中部及北方地区,其中90%以上病理类型为鳞状细胞癌(esopha-geal s