【摘要】 目的观察中西医结合治疗排卵障碍性不孕的临床疗效,探讨其作用机制。方法将60例排卵障碍性不孕患者随机分为对照组和观察组。对照组采用克罗米芬促排卵治疗,观察组在对照组治疗基础上加用自拟中药汤剂治疗,2组均连续治疗3个月经周期。观察基础体温、卵泡发育、子宫内膜厚度、排卵、妊娠情况,检测血清中雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)的水平。结果12组治疗前基础体温波动差异无统计学意义(P>0.05),治疗后,观察组明显优于对照组(P<0.05);2治疗前2组子宫内膜厚度差异无统计学意义(P>0.05),治疗后,2组子宫内膜均较治疗前显著增厚(均P<0.01),观察组较对照组明显增厚(P<0.01);3治疗后,观察组E2、LH和FSH水平的改善均优于对照组(P<0.01);4治疗后,观察组的排卵率和妊娠率均明显高于对照组(P<0.05)。结论中西医结合治疗排卵障碍性不孕有利于成熟卵泡的发育及子宫内膜生长,改善患者激素水平,提高妊娠率,值得临床推广。更多还原

【Abstract】 Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of infertility resulted from ovulation dysfunction and to probe its mechanisms.Methods Sixty patients with ovulation dysfunction were divided into observation group and control group.Both groups were given clomiphine to induce ovulation.Furthermore,the observational group was added Chinese herb recipe.Both groups were treated for 3menstruations.Basic body temperature,follicle development,endometrium depth,ovulation and pregnancy were observed.Serum levels of E2,LH and FSH were detected.Results 1There was no difference in the basic body temperature between two groups(P>0.05).However,after treatment,the basic body temperature of the observation group was obviously superior to that of control group(P<0.05).2There was no difference in the endometrium depth between two groups(P>0.05).After treatment,the endometrium in the observation group was significantly better than that in the control group(P<0.01).3After treatment,serum levels of E2,LH and FSH in the observation group were all improved more obviously than those in the control group(P<0.01).4Ovulation rate and pregnancy rate in the observation group were all significantly higher than those in the control group(P<0.05).Conclusion The method of integrated traditional Chinese and western medicine,which can promote the development of follicle and endometrium,improve levels of E2,LH and FSH and enhance ovulation rate and pregnancy rate in the treatment of infertility resulted from ovulation dysfunction,is worthy of clinical promoting.更多还原