【摘要】 目的:探讨首发精神分裂症患者的认知功能与感觉门控P50关系。方法:使用美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)轴Ⅰ临床定式检查诊断首发精神分裂症住院患者106例,86名来自社区并且年龄、性别、受教育程度与患者匹配正常对照,采用听觉条件(S1)-测试(S2)刺激范式对所有研究对象进行P50检测,检测指标为S1、S2潜伏期和波幅,S2/S1抑制率,(Sl-S2)差值。根据抑制比,将S2/S1≤0.4定义为抑制比正常,S2/S1>0.4定义为抑制比异常。采用精神分裂症认知功能成套测验中文版(MCCB)评估所有对象认知功能。结果:精神分裂症患者的S1潜伏期、S2潜伏期长于正常对照组,S1波幅、(S1-S2)波幅低于对照组,S2/S1抑制率显著高于对照组(均P<0.01);精神分裂症患者的M CCB各维度得分均低于对照组(均P<0.05)。精神分裂症患者P50抑制率正常、异常者的M CCB分测验评分及总分差异无统计学意义(均P>0.05)。多元逐步回归分析显示P50抑制率、(S1-S2)波幅与M CCB评分的相关性无统计学意义(均P>0.05)。结论:首发精神分裂症患者的认知功能可能与感觉门控P50抑制缺陷无关联。更多还原

【Abstract】 Objective:To explore the relation of cognitive function correlates to P50 sensory gating in patients with schizophrenia.Methods:Totally 106 patients with drug-naive first-episode schizophrenia and 86 healthy control subjects matched for age,sex and education were recruited.All patients met the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-IV) criteria for schizophrenia.Their cognitive function were assessed with the MATRICS Consensus Cognitive Battery(MCCB).The P50 auditory gating potential were recorded in all subjects using conditioning-testing stimulus paradigm and stimulus train paradigm.The P50 components were measured in S1 S2 latency,S1 S2 amplitude and P50 suppression ratios.Results:Compared with the controls subjects,the patients with schizophrenia had significantly longer SI[60.8±7.8) ms vs.(56.3±7.0) ms,P <0.05]S2 latency[(59.1±10.2)ms vs.(55.7±10.7)ms,P<0.05],lower S1 amplitude[(2.8±1.8)μV vs.(3.5±1.6)μV,P<0.05],less amplitude difference(S1-S2)[(1.5±1.8)μV vs.(2.2±1.4)μV,P < 0.05]and higher P50 suppression ratios(S2/S1)[(59.7 ±65.6) vs.(37.6 ±30.0),P <0.05].Schizophrenia patients had lower score than control subjects in all cognitive domains of MCCB(Ps <0.05).No differences in neurocognitive performance were found between subjects in the normal P50 ratio and the abnormal in healthy controls or patients with schizophrenia(Ps >0.05).No significant correlation was found between P50 gating measures(P50 ratio and P50 amplitude difference) and neuropsychological measures in MCCB scores(Ps >0.05).Conclusion:There may be no association between P50 deficits and cognitive measures in patients with drug-naive first-episode schizophrenia.更多还原