【摘要】 [目的]研究八宝丹联合丁二磺酸腺苷蛋氨酸治疗肝硬化合并黄疸的临床疗效。[方法]肝硬化合并黄疸患者65例,其中对照组32例,实验组33例。对照组住院期间给予静脉滴注丁二磺酸腺苷蛋氨酸针剂,1 000mg/d;出院后口服丁二磺酸腺苷蛋氨酸肠溶片,1 000 mg/d。实验组在上述基础上加用八宝丹胶囊,口服,2粒/次,3次/d。疗程均为8周。观察2组患者治疗前后症状体征,肝功能指标TBIL、ALT、AST、TAB、ALP、GGT,PT,肝纤维化指标LN、C-IV及不良反应。[结果]2组患者治疗后,症状体征、TBIL、ALT、AST、TAB、ALP、GGT都有明显改善;治疗组TBIL下降程度明显高于对照组,差异有统计学意义(P<0.001)。2组的PT无明显变化。对照组治疗后,LN增加,差异有统计学意义(P<0.001)。治疗组治疗后,LN、C-IV无明显增加。治疗组总有效率93.9%,高于对照组69.7%,差异有统计学意义(P<0.05)。2组患者均无严重不良反应发生。[结论]八宝丹联合丁二磺酸腺苷蛋氨酸对肝硬化合并黄疸的治疗效果好,安全可靠,值得临床推广。更多还原

【Abstract】 [Objective]To observe the therapeutic effect of combined therapy of Babaodan and ademetionine in patients with jaundice from cirrhosis.[Methods]Sixty-five patients of jaundice from cirrhosis were randomly divided into control group(n=32)and treatment group(n=33).Babaodan capsules(two capsules once,three times a day,for oral use)and ademetionine(1 000 mg/d intravenous drip in hospital and1 000mg/d tablets out of hospital)were given for the treatment group;the same treatments were given to the control group except Babaodan capsules.The treatment duration was 8weeks in both groups.The clinical symptoms,physical signs,liver functions(TBIL,ALT,AST,TAB,ALP and GGT),PT and indicators of hepatic fibrosis(LN,C-IV)were compared before and after treatment.[Results]After treatment,clinical symptoms,physical signs and the liver functions in both groups were better.TBIL index in treatment group were lower than those in control group,with statistically significant difference(P<0.001).There was no difference in PT between two groups.After being treated,LN got worse in control group(P<0.001).LN and C-IV did not get worse in treatment group.The total effective rate of treatment group was 93.9%,which was higher than 69.7% of control group,with statistically significant difference(P<0.05).The two groups showed no serious adverse reactions.[Conclusion]The combined treatment of Babaodan and ademetionine has good clinical efficacy and safety for the patients with jaundice from cirrhosis.更多还原