【摘要】 目的:研究慢性乙型肝炎病毒感染者维生素D缺乏程度及其在病情判断和预后评估中的作用。方法:收集慢性乙型肝炎、乙型肝炎肝硬化和乙型肝炎肝衰竭患者血清标本,ELISA检测血清25-羟维生素D3水平,同时采集患者的临床和实验室检查资料。结果:慢性乙型肝炎、乙型肝炎肝硬化和乙型肝炎肝衰竭患者血清25-羟维生素D3水平分别为(3.45±2.80)ng/ml,(3.96±1.75)ng/ml和(3.66±2.66)ng/ml。与健康对照组人员的(14.75±9.60)ng/ml相比,慢性乙型肝炎、乙型肝炎肝硬化和乙型肝炎肝衰竭患者血清25-羟维生素D3水平显著降低(P<0.001);而3组患者之间的血清25-羟维生素D3水平无显著差异(P>0.05)。另外,慢性乙型肝炎患者血清25-羟维生素D3水平与HBe Ag状态、HBVDNA载量,以及肝脏弹性指数之间无显著相关性(P>0.05)。结论:慢性乙型肝炎、乙型肝炎肝硬化、乙型肝炎肝衰竭患者普遍存在维生素D严重缺乏,但其不能判断病情的轻重,而补充维生素D可改善乙型肝炎患者的病情和预后。更多还原

【Abstract】 Objective: To investigate the extent of vitamin D deficiency in patients with hepatitis B virus( HBV) infection,and it’s role in disease progression and prognosis. Methods: Serum samples of the patients with chronic hepatitis B( CHB),liver cirrhosis( LC),or liver failure( LF) were collected. Serum levels of 25-hydroxyvitamin D3( 25( OH) D3) were determined by ELISA,the clinical manifestations and laboratory findings were collected and analyzed. Results: Serum levels of 25( OH) D3 in patients with CHB,LC,and LF were( 3. 45 ±2. 80) ng / ml,( 3. 96 ± 1. 75) ng / ml,and( 3. 66 ± 2. 66) ng / ml,respectively. Compared with the healthy control group( 14. 75 ± 9. 60)ng / ml,significantly lower levels of serum 25( OH) D3 were found in patients with CHB,LC,and LF( P < 0. 001),while there was no significant difference in serum 25( OH) D3 levels among the three groups of patients. On the other hand,serum 25( OH) D3 levels were not correlated with HBe Ag status,HBV DNA viral load,and liver stiffness. Conclusion: Severe vitamin D deficiency is prevalenced in patients with CHB,LC,and LF. Vitamin D supplementation may improve the outcome and prognosis of patients with HBV infection.更多还原