【Objective】To observe the effects of focal mild hypothermia and focal irrigation by artificial cerebrospinal fluid(ACSF) on brain edema after traumatic brain injury. 【Methods】 A total of 210 healthy adult Sprague-Dawley rats were randomly separated to sham operation group(SO group), traumatic brain injury animal model group(TBI group), focal mild hypothermia group(FH group), focal irrigation group(FI group) and focal hypothermia combined with focal irrigation group(FIH group). Each group was divided into 6 ...